Problems of Radiation Medicine and Radiobiology

S. Razavi^1,2, F. Ahmadi-Roknabadi^1,2, M. Safarian^3,4, A. Mehdipour^3,5, A. Anbarian^3,4,
M. Mirzamohammadi^3,4, M. Zeinali^3,4, M. Kazemi Arababadi^2,3

¹Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
²Dept. of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
³Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
⁴Dept of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
⁵Dept. of Radiology, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

IL-10 IS DOWN-REGULATED IN THE CARDIOVASCULAR DISEASES SUSPECTED PATIENTS, INDEPENDENT OF ANGIOGRAPHY

IL-10 and interferon-gamma (IFN-γ) are the important anti and pro-inflammatory cytokines, respectively, which may participate in the cardiovascular disease pathogenesis. Additionally, environmental factors, such as the X-ray, can modulate cytokine expression. Due to the fact that X-ray is used during angiography, hence, angiography may alter expression of the cytokines.
Objective. Accordingly, this project was aimed to assess IL-10 and IFN-γ serum levels within cardiovascular patients (with and without vessel stenosis) versus healthy controls and also the effects of angiography on the serum levels of the cytokines.
Material and methods. This study was performed on the 80 participants, including twenty cases in each group (healthy controls and cardiovascular patients without vessel stenosis, stenosis of 1 vessel and stenosis of more than 1 vessel) to evaluate IL-10 and IFN-γ serum levels using ELISA technique. The IL-10 and IFN-γ serum levels also compared within group 2, 3 and 4 before and after angiography to explore the effects of the technique on the IL-10 and IFN-γ serum levels.
Results. IL-10, but not IFN-γ, serum levels were higher in the healthy controls than all cardiovascular patients. IL-10 and IFN-γ serum levels were not altered after angiography and also were not differ in the smoker versus nonsmoker and opium consuming versus non-opium consuming participants. Conclusion. Due to the results it may be concluded that IL-10 can be considered as a plausible inhibitor of cardiovascular diseases independent of angiography duration and X-ray, however, IFN-γ has no effects in the Iranian patients suffering from cardiovascular diseases.
Key words: angiography, X-ray, IL-10 and IFN-γ.

Problems of Radiation Medicine and Radiobiology.
2019;24:449-454. doi: 10.33145/2304-8336-2019-24-449-454

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