|
D. Marazziti1, A. Piccinni1, F. Mucci1, S. Baroni1, K. Loganovsky2, T. Loganovskaja2
1Dipartimento di Medicina Clinica e Sperimentale Section of Psychiatry, University of Pisa, Via Roma,67, I"56100, Pisa, Italy
2Department of Radiation Psychoneurology, Institute of Clinical Radiology, State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine", 53 Melnikova Street, Kyiv, 04050, Ukraine
Ionizing radiation: brain effects and related neuropsychiatric manifestations
Recently, an increasing interest has been directed towards the investigation of brain effects of ionizing radiation
(IR), as it is now evident that, depending on the doses, the damages character and severity, as well as clinical manifestations are different. They are generally considered to be the result of a blending of atherosclerotic, cardiovascular, cerebrovascular and neurodegenerative processes. Further, an ongoing debate has been opened on the possible brain abnormalities following medical radiation from X-ray in interventional radiology and nuclear medicine
procedures that would involve both patients and medical workers. The aim of the present paper is to summarize
literature data on brain effects of IR exposure, with a special focus on those gathered by some of the authors after
the Chornobyl nuclear plant disaster, and how they can be related to the pathophysiology of different neuropsychiatric disorders.
Key words: ionizing radiation, brain, Chornobyl disaster, neuropsychiatric disorders, neurogenesis, hippocampus, neuroinflammation, atherosclerosis.
Problems of radiation medicine and radiobiology. 2016;21:64-90.
|
full text